Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219719
Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Sprouting angiogenesis is a core biological process critical to vascular
development. Its accurate simulation, relevant to multiple facets of human
health, is of broad, interdisciplinary appeal. This study presents an in-silico
model replicating a microfluidic assay where endothelial cells sprout into a
biomimetic extracellular matrix, specifically, a large-pore, low-concentration
fibrin-based porous hydrogel, influenced by chemotactic factors. We introduce
a novel approach by incorporating the extracellular matrix and chemotactic factor
effects into a unified term using a single parameter, primarily focusing on
modelling sprouting dynamics and morphology. This continuous model
naturally describes chemotactic-induced sprouting with no need for additional
rules. In addition, we extended our base model to account for matrix sensing and
degradation, crucial aspects of angiogenesis. We validate our model via a hybrid
in-silico experimental method, comparing the model predictions with
experimental results derived from the microfluidic setup. Our results
underscore the intricate relationship between the extracellular matrix structure
and angiogenic sprouting, proposing a promising method for predicting the
influence of the extracellular matrix on angiogenesis.
Subject
Subject (English)
Citation
Citation
FERRÉ TORRES, Josep, et al. Modelling of chemotatic sprouting endothelial cells through and extracellular matrix. Frontiers In Bioengineering And Biotechnology. 2023. ISSN 2296-4185. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/219719