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Article

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Published version

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2014-09-30

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cc-by (c) Navarro et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/64765

Potential of caveolae in the therapy of cardiovascular and neurological diseases.

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http://dx.doi.org/10.3389/fphys.2014.00370

Abstract

Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.

Subject

Malalties del sistema nerviós, Membranes cel·lulars, Malalties cardiovasculars, Proteïnes de membrana

Subject (English)

Nervous system Diseases, Cell membranes, Cardiovascular diseases, Membrane proteins

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citation

NAVARRO BRUGAL, Gemma, et al. Potential of caveolae in the therapy of cardiovascular and neurological diseases. Frontiers in Physiology . 2014. Vol. 5, num. 1-8. ISSN 1664-042X. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/64765

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