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cc-by (c) Navarro et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/64765

Potential of caveolae in the therapy of cardiovascular and neurological diseases.

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Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.

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NAVARRO BRUGAL, Gemma, BORROTO ESCUELA, Dasiel oscar, FUXE, Kjell, FRANCO FERNÁNDEZ, Rafael. Potential of caveolae in the therapy of cardiovascular and neurological diseases.. _Frontiers in Physiology _. 2014. Vol. 5, núm. 1-8. [consulta: 23 de gener de 2026]. ISSN: 1664-042X. [Disponible a: https://hdl.handle.net/2445/64765]

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