Potential of caveolae in the therapy of cardiovascular and neurological diseases.

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dc.contributor.authorNavarro Brugal, Gemma
dc.contributor.authorBorroto Escuela, Dasiel Oscar
dc.contributor.authorFuxe, Kjell
dc.contributor.authorFranco Fernández, Rafael
dc.date.accessioned2015-04-08T13:23:30Z
dc.date.available2015-04-08T13:23:30Z
dc.date.issued2014-09-30
dc.date.updated2015-04-08T13:23:31Z
dc.description.abstractCaveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec649524
dc.identifier.issn1664-042X
dc.identifier.pmid25324780
dc.identifier.urihttps://hdl.handle.net/2445/64765
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.3389/fphys.2014.00370
dc.relation.ispartofFrontiers in Physiology , 2014, vol. 5, p. 1-8
dc.relation.urihttp://dx.doi.org/10.3389/fphys.2014.00370
dc.rightscc-by (c) Navarro et al., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationMalalties del sistema nerviós
dc.subject.classificationMembranes cel·lulars
dc.subject.classificationMalalties cardiovasculars
dc.subject.classificationProteïnes de membrana
dc.subject.otherNervous system Diseases
dc.subject.otherCell membranes
dc.subject.otherCardiovascular diseases
dc.subject.otherMembrane proteins
dc.titlePotential of caveolae in the therapy of cardiovascular and neurological diseases.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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