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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/189708
Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs
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[eng] The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic strategies through the design, synthesis and pharmacological evaluation of various families of compounds aimed at treating diseases that currently do not have a therapeutic solution. In the first chapter, the steps followed for the development, in its preclinical phase, of a representative compound that was the object of intellectual protection by the Fundació Bosch i Gimpera (UB) are explained. In the second chapter, the synthetic studies resulting from the exploration of the reactivity of different positions of the family of bicyclic α-iminophosphonates are exposed, which have allowed access to new structures that have been subjected to pharmacological evaluation. Specifically, it has been possible to access a family of compounds that have shown a very relevant biological activity and with potential application to Alzheimer's disease, whose diffusion will be preserved as it is being evaluated for intellectual protection by of the Bosch i Gimpera Foundation. In the third chapter, the synthetic studies resulting from the in-depth study of a multicomponent reaction that has given rise to a family of compounds with antiproliferative activity in a glioblastoma cell line are presented. This activity is similar to that of the drug used in the first line of treatment and, therefore, preliminary studies have been carried out that have made it possible to characterize the representative compound, promoting its development at the preclinical level. In the fourth chapter, a family of compounds that inhibit an enzyme directly related to inflammatory processes is provided. This new family has improved metabolic characteristics compared to previous families developed in the group and that were the subject of intellectual protection. The fifth chapter includes results derived from joint work with collaborating research groups, aimed at finding new applications for both compounds already previously published by us, with which we continue to work, and new compounds that we are developing.
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BAGÁN POLONIO, Andrea. Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs. [consulta: 3 de desembre de 2025]. [Disponible a: https://hdl.handle.net/2445/189708]