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2017-02-01

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cc-by-nc (c) Fountoulakis, Konstantinos N. et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/116264

The International College of Neuropsychopharmacology (CINP) treatment guidelines for Bipolar disorder in adults (CINP-BD-2017), part 2: Review, grading of the evidence and a precise algorithm

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Recurs relacionat

http://doi.org/10.1093/ijnp/pyw100
 http://hdl.handle.net/2445/116263
 http://hdl.handle.net/2445/116265
 http://hdl.handle.net/2445/116267

Resum

BACKGROUND: The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety. MATERIAL AND METHODS: The PRISMA method was used in the literature search with the combination of the words 'bipolar,' 'manic,' 'mania,' 'manic depression,' and 'manic depressive' with 'randomized,' and 'algorithms' with 'mania,' 'manic,' 'bipolar,' 'manic-depressive,' or 'manic depression.' Relevant web pages and review articles were also reviewed. RESULTS: The current report is based on the analysis of 57 guideline papers and 531 published papers related to RCTs, reviews, posthoc, or meta-analysis papers to March 25, 2016. The specific treatment options for acute mania, mixed episodes, acute bipolar depression, maintenance phase, psychotic and mixed features, anxiety, and rapid cycling were evaluated with regards to efficacy. Existing treatment guidelines were also reviewed. Finally, Tables reflecting efficacy and recommendation levels were created that led to the development of a precise algorithm that still has to prove its feasibility in everyday clinical practice. CONCLUSIONS: A systematic literature search was conducted on the pharmacological treatment of bipolar disorder to identify all relevant random controlled trials pertaining to all aspects of bipolar disorder and graded the data according to a predetermined method to develop a precise treatment algorithm for management of various phases of bipolar disorder. It is important to note that the some of the recommendations in the treatment algorithm were based on the secondary outcome data from posthoc analyses.

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Podeu consultar la part 1: http://hdl.handle.net/2445/116263
Podeu consultar la part 3: http://hdl.handle.net/2445/116265
Podeu consultar la part 4: http://hdl.handle.net/2445/116267

Matèries

Trastorn bipolar, Adults, Farmacologia

Matèries (anglès)

Manic-depressive illness, Methodology, Adulthood, Pharmacology

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

FOUNTOULAKIS, Konstantinos n., YATHAM, Lakshmi, GRUNZE, Heinz, VIETA I PASCUAL, Eduard, YOUNG, Allan, BLIER, Pierre, KASPER, Siegfried, MOELLER, Hans j.. The International College of Neuropsychopharmacology (CINP) treatment guidelines for Bipolar disorder in adults (CINP-BD-2017), part 2: Review, grading of the evidence and a precise algorithm. _International Journal of Neuropsychopharmacology_. 2017. Vol. 20, núm. 2, pàgs. 121-179. [consulta: 23 de gener de 2026]. ISSN: 1461-1457. [Disponible a: https://hdl.handle.net/2445/116264]

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