Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

100936.pdf (395.65 KB)

Document type

Article

Version

Published version

Publication date

2018-09-24

Publication license

cc-by (c) Ferrer-Martínez, Andreu et al., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223531

Use of adenoviral vectors with a minimal cytomegalovirus promoter

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.2144/03343dd02

Abstract

E1-deleted recombinant adenoviruses 5 are widely used as gene vectors for basic and clinical research. Most adenoviral constructions bear an expression cassette inserted into the E1 region of their genome close to the 5′ end and include a heterologous promoter. The major immediate early human cytomegalovirus (hCMV) and the Rous sarcoma virus promoters, which have fairly high and consistent activity, are among the most extensively used. Nevertheless, expression of delivered protein from these promoters is often excessive, and weaker transcriptional activity would be desirable.

Subject

Animals, Cèl·lules, Citomegalovirus, Adenovirus

Subject (English)

Animals, Cells, Cytomegaloviruses, Adenoviruses

Citation

Collections

Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citation

FERRER-MARTÍNEZ, Andreu, GARCÍA MARTÍNEZ, Celia and GÓMEZ FOIX, Anna Maria. Use of adenoviral vectors with a minimal cytomegalovirus promoter. Biotechniques. 2018. Vol. 34, num. 3. ISSN 0736-6205. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/223531

Export metadata

JSON - METS

Share record