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Article

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Accepted version

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2015-11

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/99565

Polyamidoamine nanoparticles as nanocarriers for the drug delivery to malaria parasite stages in the mosquito vector

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http://dx.doi.org/10.2217/nnm.15.174

Abstract

Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial compounds exclusively to Plasmodium-infected cells, thus increasing drug efficacy and minimizing the induction of resistance to newly developed therapeutic agents. Polyamidoamine-derived nanovectors combine into a single chemical structure drug encapsulating capacity, antimalarial activity, low unspecific toxicity, specific targeting to Plasmodium, optimal in vivo activity and affordable synthesis cost. After having shown their efficacy in targeting drugs to intraerythrocytic parasites, now polyamidoamines face the challenge of spearheading a new generation of nanocarriers aiming at the malaria parasite stages in the mosquito vector.

Subject

Malària, Malalties parasitàries

Subject (English)

Malaria, Parasitic diseases

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Articles publicats en revistes (ISGlobal)

Citation

URBÁN, Patricia, RANUCCI, Elisabetta and FERNÀNDEZ BUSQUETS, Xavier. Polyamidoamine nanoparticles as nanocarriers for the drug
                delivery to malaria parasite stages in the mosquito vector. Nanomedicine. 2015. Vol. 10, num. 22, pags. 3401-3414. ISSN 1743-5889. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/99565

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