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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174434
Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer
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A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30-0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.
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LINARES GALIANA, Isabel, BERENGUER FRANCÉS, Miguel ángel, CAÑAS CORTÉS, Rut, PUJOL CANADELL, Monica, COMAS ANTÓN, Silvia, MARTÍNEZ, Evelyn, LAPLANA, Maria, PÉREZ MONTERO, Héctor, PLA FARNÓS, María jesús, NAVARRO MARTÍN, Arturo, NUÑEZ, Miriam, BOTH, Brigitte, GUEDEA EDO, Ferran. Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer. _Journal of Radiation Research_. 2021. Vol. 62, núm. 1, pàgs. 110-118. [consulta: 21 de gener de 2026]. ISSN: 0449-3060. [Disponible a: https://hdl.handle.net/2445/174434]