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2021-12-30

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cc-by (c) Alé Chilet, Aníbal et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198680

Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.

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Recurs relacionat

https://doi.org/10.3390/jcm11010197

Resum

The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imaging tests and bloods, was performed. OCTA parameters included vessel density (VD), perfusion density (PD), foveal avascular zone area (FAZa), perimeter (FAZp) and circularity (FAZc) in the superficial vascular plexus, and DKD categories were defined according to glomerular filtration rate (GFR), albumin-creatinine ratio (ACR) and KDIGO prognosis risk classifications. A total of 425 individuals (1 eye/1 patient) were included. Reduced VD and FAZc were associated with greater categories of GFR (p = 0.002, p = 0.04), ACR (p = 0.003, p = 0.005) and KDIGO risk prognosis classifications (p = 0.002, p = 0.005). FAZc was significantly reduced in greater KDIGO prognosis risk categories (low risk vs. moderate risk, 0.65 ± 0.09 vs. 0.60 ± 0.07, p < 0.05). VD and FAZc presented the best diagnostic performance in ROCs. In conclusion, OCTA parameters, such as VD and FAZc, are able to detect different GFR, ACR, and KDIGO categories in T1DM patients and controls in a non-invasive, objective quantitative way. FAZc is able to discriminate within T1DM patients those with greater DKD categories and greater risk of DKD progression.

Matèries

Diabetis, Nefropaties diabètiques, Malalties del ronyó, Moviments oculars, Tomografia de coherència òptica

Matèries (anglès)

Diabetes, Diabetic nephropathies, Kidney diseases, Eye movements, Optical coherence tomography

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ALÉ CHILET, Aníbal raimundo, BERNAL MORALES, Carolina, BARRASO, Marina, HERNÁNDEZ, Teresa, OLIVA, Cristian, VINAGRE, Irene, ORTEGA MARTÍNEZ DE VICTORIA, Emilio, FIGUERAS ROCA, Marc, SALA PUIGDOLLERS, Anna, ESQUINAS LÓPEZ, Cristina, GIMÉNEZ, Marga, ESMATJES MOMPÓ, Enric, ADÁN CIVERA, Alfredo, ZARRANZ VENTURA, Javier. Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.. _Journal of Clinical Medicine_. 2021. Vol. 11, núm. 1, pàgs. 197. [consulta: 23 de gener de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/198680]

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