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2024-06-25

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cc-by-nc-nd (c) Santos Pérez, Salud et al., 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220639

Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain

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https://doi.org/10.1016/j.rec.2024.06.003

Abstract

Introduction and objectives: This real-world study-the first of its kind in a Spanish population-aimed to explore severe risk for cardiovascular events and all-cause death following exacerbations in a large cohort of patients with chronic obstructive pulmonary disease (COPD). Methods: We included individuals with a COPD diagnosis code between 2014 and 2018 from the BIG-PAC health care claims database. The primary outcome was a composite of a first severe cardiovascular event (acute coronary syndrome, heart failure decompensation, cerebral ischemia, arrhythmia) or all-cause death following inclusion in the cohort. Time-dependent Cox proportional hazards models estimated HRs for associations between exposed time periods (1-7, 8-14, 15-30, 31-180, 181-365, and >365 days) following an exacerbation of any severity, and following moderate or severe exacerbations separately (vs unexposed time before a first exacerbation following cohort inclusion). Results: During a median follow-up of 3.03 years, 18 901 of 24 393 patients (77.5%) experienced ≥ 1 moderate/severe exacerbation, and 8741 (35.8%) experienced the primary outcome. The risk of a severe cardiovascular event increased following moderate/severe COPD exacerbation onset vs the unexposed period, with rates being most increased during the first 1 to 7 days following exacerbation onset (HR, 10.10; 95%CI, 9.29-10.97) and remaining increased >365 days after exacerbation onset (HR, 1.65; 95%CI, 1.49-1.82). Conclusions: The risk of severe cardiovascular events or death increased following moderate/severe exacerbation onset, illustrating the need for proactive multidisciplinary care of patients with COPD to prevent exacerbations and address other cardiovascular risk factors.

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Mortalitat, Malalties pulmonars obstructives cròniques, Malalties cardiovasculars

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Mortality, Chronic obstructive pulmonary diseases, Cardiovascular diseases

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

SANTOS PÉREZ, Salud, et al. Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain. Revista Española de Cardiología. 2024. Vol. 78, num. 2, pags. 138-150. ISSN 0300-8932. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/220639

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