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2019-05-01

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cc-by (c) Benito Hernández, M. Natividad de et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176155

The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms

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https://doi.org/10.3390/jcm8050673

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The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and 'positive intraoperative cultures' (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.

Matèries

Infeccions, Pròtesis, Etiologia

Matèries (anglès)

Infections, Prosthesis, Etiology

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BENITO HERNÁNDEZ, M. natividad de, MUR, Isabel, RIBERA PUIG, Alba, SORIANO VILADOMIU, Alex, RODRÍGUEZ-PARDO, Dolors, SORLI, Luisa, COBO REINOSO, Javier, FERNÁNDEZ SAMPEDRO, Marta, TORO, Maria dolores del, GUIO, Laura, PRAENA SEGOVIA, Julia, BAHAMONDE, Alberto, RIERA, Melchor, ESTEBAN, Jaime, BARAIA ETXABURU, Josu, MARTÍNEZ-ALVAREZ, Jesús, JOVER SÁENZ, Alfredo, DUEÑAS, Carlos j., RAMOS MARTÍNEZ, Antonio, SOBRINO, Beatriz, EUBA, Gorane, MORATA, Laura, PIGRAU, Carles, HORCAJADA GALLEGO, Juan pablo, COLL, Pere, CRUSI, Xavier, ARIZA CARDENAL, Javier, REIPI (Spanish Network for Research in Infectious Disease) Group for the Study of Prosthetic Joint Infections, SEIMC (Spanish Society of Infectious Diseases). The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms. _Journal of Clinical Medicine_. 2019. Vol. 8, núm. 5, pàgs. 673. [consulta: 23 de gener de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/176155]

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