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2015-04-15

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cc-by (c) Bu, Pengcheng et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/125584

miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

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https://doi.org/10.1038/ncomms7879

Abstract

As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. Here we show that miR-1269a promotes colorectal cancer (CRC) metastasis and forms a positive feedback loop with TGF-β signalling. miR-1269a is upregulated in late-stage CRCs, and long-term monitoring of 100 stage II CRC patients revealed that miR-1269a expression in their surgically removed primary tumours is strongly associated with risk of CRC relapse and metastasis. Consistent with clinical observations, miR-1269a significantly increases the ability of CRC cells to invade and metastasize in vivo. TGF-β activates miR-1269 via Sox4, while miR-1269a enhances TGF-β signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop. Our findings suggest that miR-1269a is a potential marker to inform adjuvant chemotherapy decisions for CRC patients and a potential therapeutic target to deter metastasis.

Subject

Càncer, Quimioteràpia del càncer, Metàstasi

Subject (English)

Cancer, Cancer chemotherapy, Metastasis

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

BU, Pengcheng, et al. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. Nature Communications. 2015. Vol. 15, num. 6, pags. 6879. ISSN 2041-1723. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/125584

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