Files

649173.pdf (373.52 KB)

Document type

Article

Version

Accepted version

Publication date

2015-02-10

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127700

Pd0-Catalyzed Intramoleculara-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1002/chem.201406305

Abstract

A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. KEYWORDS: arylation; domino reactions; nitrogen heterocycles; palladium; sulfones

Subject

Compostos heterocíclics, Compostos de nitrogen, Compostos de sofre, Pal·ladi (Element químic), Síntesi orgànica

Subject (English)

Heterocyclic compounds, Nitrogen compounds, Sulfur compounds, Palladium, Organic synthesis

Citation

Collections

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

SOLÉ ARJÓ, Daniel, PÉREZ JANER, Ferran and MANCUSO, Raffaella. Pd0-Catalyzed Intramoleculara-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines. Chemistry-A European Journal. 2015. Vol. 21, num. 12, pags. 4580-4584. ISSN 0947-6539. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/127700

Export metadata

JSON - METS

Share record