Pd0-Catalyzed Intramoleculara-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines

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dc.contributor.authorSolé Arjó, Daniel
dc.contributor.authorPérez Janer, Ferran
dc.contributor.authorMancuso, Raffaella
dc.date.accessioned2019-01-29T12:04:46Z
dc.date.available2019-01-29T12:04:46Z
dc.date.issued2015-02-10
dc.date.updated2019-01-29T12:04:46Z
dc.description.abstractA new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. KEYWORDS: arylation; domino reactions; nitrogen heterocycles; palladium; sulfones
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec649173
dc.identifier.issn0947-6539
dc.identifier.pmid25677083
dc.identifier.urihttps://hdl.handle.net/2445/127700
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/chem.201406305
dc.relation.ispartofChemistry-A European Journal, 2015, vol. 21, num. 12, p. 4580-4584
dc.relation.urihttps://doi.org/10.1002/chem.201406305
dc.rights(c) Wiley-VCH, 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationCompostos heterocíclics
dc.subject.classificationCompostos de nitrogen
dc.subject.classificationCompostos de sofre
dc.subject.classificationPal·ladi (Element químic)
dc.subject.classificationSíntesi orgànica
dc.subject.otherHeterocyclic compounds
dc.subject.otherNitrogen compounds
dc.subject.otherSulfur compounds
dc.subject.otherPalladium
dc.subject.otherOrganic synthesis
dc.titlePd0-Catalyzed Intramoleculara-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)