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Steroid hormones interrelationships in the metabolic syndrome: an introduction to the ponderostat hypothesis

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Sexual dimorphism in the metabolic syndrome. The clairvoyant early implication of sex hormones in the characterization of the metabolic syndrome (MS) was detected early, and in accordance with the well-known sex-related main patterns of fat deposition in obesity: gynoid and android. The differences point to a direct implication of androgens and estrogens in the development, properties and maintenance of obesity and, by extension, to the cumulus of diseases grouped in the MS. For a long time, the key issue of the MS, i.e. the metabolic event explaining (and justifying) most of the derangements of the MS, has been considered to be insulin resistance (...)

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ALEMANY, Marià. Steroid hormones interrelationships in the metabolic syndrome: an introduction to the ponderostat hypothesis. Hormones. International Journal Of Endocrinology And Metabolism. 2012. Vol. 11, num. 3, pags. 272-289. ISSN 1109-3099. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/53849

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