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2012-12-08

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/232076

Identificación de las características clínicas y alteraciones analíticas asociadas a la fractura vertebral en mujeres con osteoporosis posmenopáusica

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Background and objective: Vertebral fractures (VF) are a major risk factor for the development of further fractures. Therefore, it is important to identify clinical risk factors and laboratory abnormalities related to VF. We aimed to analyse clinical and biochemical alterations related to the presence of radiological VF in postmenopausal women with osteoporosis. Patients and methods: Two-hundred and four postmenopausal women with osteoporosis (aged 64,9 [10] years) who were referred to an outpatient Rheumatology Unit were prospectively included. Bone mineral density (BMD), spine X-ray, and laboratory tests were performed in all participants before treatment. Results: Twenty-eight per cent of patients had VF. Comparing women with and without VF, those with fractures were older (71.9 [10] vs 61.8 [8,6], P<.001), had lower stature (152 [7.2] vs 155 [6.2], P=.01), lower total hip T-score values (-2.2 [0,9] vs -1.9 [0.8], P=.041), higher prevalence of non-VF (38 vs 30%, P=.04) and a higher prevalence of low serum 25(OH)D levels (69 vs 53%, P<.05). In logistic regression analysis, age and BMD at the total hip were independent predictors of VF. Patients over 65 presented a higher frequency of VF (47 vs 12%, P<.0001). In addition, a T-score lower than -2,5 at the total hip was associated with an increased risk of VF (OR 2.5; 95% CI 1.2-4.9). Conclusions: Over the age of 65 nearly half of the postmenopausal women with osteoporosis have VF and a higher prevalence of low 25(OH)D serum measurements. Spinal X-ray and 25(OH)D serum measurements are especially indicated in this group of women since it influences the therapeutic approach.

Recurs relacionat

https://doi.org/10.1016/j.medcli.2011.11.033

Matèries

Menopausa, Fractures, Factors de risc en les malalties

Matèries (anglès)

Menopause, Fractures, Risk factors in diseases

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

CERDÀ, Dacia, et al. Identificación de las características clínicas y alteraciones analíticas asociadas a la fractura vertebral en mujeres con osteoporosis posmenopáusica. Medicina Clinica. 2012. Vol. 139, num. 14, pags. 626-630. ISSN 0025-7753. [consulted: 21 of October of 2026]. Available at: https://hdl.handle.net/2445/232076

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