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2016

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cc-by (c) Ortiz, Fernanda et al., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/112003

Decreased kidney graft survival in low immunological risk patients showing inflammation in normal protocol biopsies

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https://doi.org/10.1371/journal.pone.0159717

Abstract

Introduction The pros and cons for implementing protocol biopsies (PB) after kidney transplantation are still a matter of debate. We aimed to address the frequency of pathological findings in PB, to analyze their impact on long-term graft survival (GS) and to analyze the risk factors predicting an abnormal histology. Methods We analyzed 946 kidney PB obtained at a median time of 6.5 (±2.9) months after transplantation. Statistics included comparison between groups, Kaplan-Meier and multinomial logistic regression analysis. Results and Discussion PB diagnosis were: 53.4% normal; 46% IFTA; 12.3% borderline and 4.9% had subclinical acute rejection (SCAR). Inflammation had the strongest negative impact on GS. Therefore we split the cases into: "normal without inflammation", "normal with inflammation", "IFTA without inflammation", "IFTA with inflammation" and "rejection" (including SCAR and borderline). 15-year GS in PB diagnosed normal with inflammation was significantly decreased in a similar fashion as in rejection cases. Among normal biopsies, inflammation increased significantly the risk of 15-y graft loss (P = 0.01). Variables that predicted an abnormal biopsy were proteinuria, previous AR and DR-mismatch. Conclusion We conclude that inflammation in normal PB is associated with a significantly lower 15-y GS, comparable to rejection or IFTA with inflammation.

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Inflamació, Biòpsia, Histologia

Subject (English)

Inflammation, Biopsy, Histology

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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ORTIZ, Fernanda, et al. Decreased kidney graft survival in low immunological risk patients showing inflammation in normal protocol biopsies. PLoS One. 2016. Vol. 11, num. 8, pags. e0159717. ISSN 1932-6203. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/112003

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