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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222240
Matching-adjusted indirect comparison of selpercatinib and pralsetinib in RET fusion–positive non–small cell lung cancer
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AimsSelpercatinib and pralsetinib are approved for RET-rearranged non - small cell lung cancer.Materials & methodsEfficacy and safety were compared using matching-adjusted indirect comparison.ResultsMedian progression-free survival (PFS) was 22.1 and 13.3 months for selpercatinib and pralsetinib, respectively (HR = 0.67; 95% CI, 0.53-0.85). Objective response rate was 64.5% and 65.8%, and disease control rate was 92.1% and 90.4%, respectively. Median overall survival was not reached for selpercatinib and 43.9 months for pralsetinib (HR = 0.81; 95% CI, 0.60-1.09). Grade >= 3 treatment-related adverse events (TRAEs) were reported in 39.3% and 62.6% of patients, with discontinuations due to TRAEs in 3.6% and 10.0% of patients, respectively.ConclusionOutcomes were similar; however, PFS was significantly prolonged with selpercatinib, with fewer grade >= 3 TRAEs.
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HOCHMAIR, Maximilian, KIISKINEN, Urpo, D’YACHKOVA, Yulia, PURI, Tarun, WANG, Xuwen, WOLOWACZ, Sorrel, VICKERS, Adrian, NADAL, Ernest. Matching-adjusted indirect comparison of selpercatinib and pralsetinib in RET fusion–positive non–small cell lung cancer. _Future Oncology_. 2025. Vol. 21, núm. 15, pàgs. 1867-1878. [consulta: 26 de febrer de 2026]. ISSN: 1744-8301. [Disponible a: https://hdl.handle.net/2445/222240]