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2005

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/18674

Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.

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http://dx.doi.org/10.1136/gut.2003.036558

Abstract

with specific ANA, in particular of the IgG3 isotype, had significantly more severe biochemical and histological disease compared with those who were seronegative. None of the controls was positive. Conclusions: Disease specific ANA are present in the majority of patients with PBC when investigated at the level of immunoglobulin isotype. PBC specific ANA, in particular of the IgG3 isotype, are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage.

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Autoanticossos, Malalties autoimmunitàries, Cirrosi hepàtica

Subject (English)

Autoantibodies, Autoimmune diseases, Hepatic cirrhosis

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RIGOPOULOU, E. I., et al. Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis. Gut. 2005. Vol. 54, num. 4, pags. 528-532. ISSN 0017-5749. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/18674

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