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PIIS2468024921012791.pdf (703.64 KB)

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2021-09-01

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cc by-nc-nd (c) Buxeda, Anna et al, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180392

Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19

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https://doi.org/10.1016/j.ekir.2021.06.023

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Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidney transplant recipients. Methods: We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treated with remdesivir. Outcomes and safety were assessed. Results: Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5 years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) required mechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged ≥65 years (45% vs. 3.2% in younger patients). Acute kidney injury was present in 27.7% of patients, but was diagnosed in 50% before treatment. No patients required remdesivir discontinuation because of adverse events. We did not find significant hepatoxicity or systemic symptoms resulting from the drug. Conclusion: In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renal and hepatic toxicity, but randomized trials are needed to assess its efficacy.

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SARS-CoV-2, Trasplantament renal

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SARS-CoV-2, Kidney transplantation

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BUXEDA, Anna, ARIAS CABRALES, Carlos, PÉREZ SÁEZ, María josé, CACHO, Judit, CABELLO PELEGRIN, Sheila, MELILLI, Edoardo, ALADRÉN, María josé, GALEANO, Cristina, LORENZO, Inmaculada, MAZUECOS, Auxiliadora, SAURA, Isabel maría, FRANCO, Antonio, RUIZ FUENTES, María del carmen, SÁNCHEZ CÁMARA, Luis alberto, SIVERIO, Orlando, MARTIN, María luisa, GONZÁLEZ GARCÍA, Elena, LÓPEZ, Verónica, MARTIN MORENO, Paloma leticia, MOINA, Iñigo, MORAL BERRIO, Esperanza, MORESO, Francesc, PORTOLÉS, José, SANTANA ESTUPIÑÁN, Raquel, ZÁRRAGA, Sofía, CANAL, Cristina, SÁNCHEZ ÁLVAREZ, Emilio, PASCUAL, Julio (pascual santos), CRESPO, Marta. Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19. _Kidney International Reports_. 2021. Vol. 6, núm. 9, pàgs. 2305-2315. [consulta: 29 de gener de 2026]. ISSN: 2468-0249. [Disponible a: https://hdl.handle.net/2445/180392]

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