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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/180392
Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
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Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidney transplant recipients. Methods: We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treated with remdesivir. Outcomes and safety were assessed. Results: Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5 years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) required mechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged ≥65 years (45% vs. 3.2% in younger patients). Acute kidney injury was present in 27.7% of patients, but was diagnosed in 50% before treatment. No patients required remdesivir discontinuation because of adverse events. We did not find significant hepatoxicity or systemic symptoms resulting from the drug. Conclusion: In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renal and hepatic toxicity, but randomized trials are needed to assess its efficacy.
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BUXEDA, Anna, et al. Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19. Kidney International Reports. 2021. Vol. 6, num. 9, pags. 2305-2315. ISSN 2468-0249. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/180392