Linkage of DNA methylation quantitative trait loci to human cancer risk

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dc.contributor.authorHeyn, Holger
dc.contributor.authorSayols, Sergi
dc.contributor.authorMoutinho, Cátia
dc.contributor.authorVidal, Enrique
dc.contributor.authorSanchez-Mut, Jose Vicente
dc.contributor.authorStefansson, Olafur A.
dc.contributor.authorNadal, Ernest
dc.contributor.authorMoran, Sebastian
dc.contributor.authorEyfjord, Jorunn E.
dc.contributor.authorGonzález Suárez, Eva
dc.contributor.authorPujana Genestar, M. Ángel
dc.contributor.authorEsteller, Manel
dc.date.accessioned2016-02-09T15:35:47Z
dc.date.available2016-02-09T15:35:47Z
dc.date.issued2014-04-24
dc.description.abstractEpigenetic regulation and, in particular, DNA methyl- ation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts. We propose that interrogating the interplay between polymorphic alleles and DNA methylation is a power- ful method for improving our interpretation of risk alleles identified in genome-wide association studies that otherwise lack mechanistic explanation. We integrated patient cancer risk genotype data and genome-scale DNA methylation profiles of 3,649 pri- mary human tumors, representing 13 solid cancer types. We provide a comprehensive meQTL catalog containing DNA methylation associations for 21% of interrogated cancer risk polymorphisms. Differen- tially methylated loci harbor previously reported and as-yet-unidentified cancer genes. We suggest that such regulation at the DNA level can provide a considerable amount of new information about the biology of cancer-risk alleles.ca
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn2211-1247
dc.identifier.pmid24703846
dc.identifier.urihttps://hdl.handle.net/2445/69344
dc.language.isoengca
dc.publisherElsevier Inc.ca
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1016/j.celrep.2014.03.016
dc.relation.ispartofCell Reports, 2014, vol. 7, pp. 331–338
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/268626/EU//EPINORC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/282510/EU//BLUEPRINT
dc.relation.urihttp://dx.doi.org/10.1016/j.celrep.2014.03.016
dc.rightscc by (c) Heyn et al., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationADN
dc.subject.classificationMetilació
dc.subject.classificationCàncer
dc.subject.classificationEpigènesi
dc.subject.classificationMarcadors genètics
dc.subject.otherDNA
dc.subject.otherMethylation
dc.subject.otherCancer
dc.subject.otherEpigenesis
dc.subject.otherGenetic markers
dc.titleLinkage of DNA methylation quantitative trait loci to human cancer riskca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/publishedVersion

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