Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181711
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods: We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results: An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor's bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient's mice. Conclusion: These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.
Matèries
Matèries (anglès)
Citació
Citació
ARNORIAGA RODRÍGUEZ, María, MAYNERIS PERXACHS, Jordi, CONTRERAS RODRÍGUEZ, Oren, BUROKAS, Aurelijus, ORTEGA SANCHEZ, Juan antonio, BLASCO, Gerard, COLL, Claudia, BIARNÉS, Carles, CASTELLS NOBAU, Anna, PUIG, Josep, GARRE OLMO, Josep, RAMOS, Rafel, PEDRAZA, Salvador, BRUGADA, Ramon, VILANOVA, Joan c., SERENA, Joaquín, BARRETINA, Jordi, GICH, Jordi, PÉREZ BROCAL, Vicente, MOYA, Andrés, FERNÁNDEZ REAL, Xavier, RAMIO TORRENTÀ, Lluís, PAMPLONA, Reinald, SOL, Joaquim, JOVÉ, Mariona, RICART, Wifredo, PORTERO-OTIN, Manuel, MALDONADO, Rafael, FERNÁNDEZ REAL, Jose manuel. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. _Gut_. 2021. Vol. 70, núm. 12, pàgs. 2283-2296. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/181711]