Carregant...
Fitxers
Tipus de document
ArticleData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177519
RTP801 regulates motor cortex synaptic transmission and learning
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death in in vitro and in vivo models of Parkinson's and Huntington's diseases and is up regulated in compromised neurons in human postmortem brains of both neurodegenerative disorders. Indeed, in both Parkinson's and Huntington's disease mouse models, RTP801 knockdown alleviates motor-learning deficits. Results: We investigated the physiological role of RTP801 in neuronal plasticity and we found RTP801 in rat, mouse and human synapses. The absence of RTP801 enhanced excitatory synaptic transmission in both neuronal cultures and brain slices from RTP801 knock-out (KO) mice. Indeed, RTP801 KO mice showed improved motor learning, which correlated with lower spine density but increased basal filopodia and mushroom spines in the motor cortex layer V. This paralleled with higher levels of synaptosomal GluA1 and TrkB receptors in homogenates derived from KO mice motor cortex, proteins that are associated with synaptic strengthening.Conclusions: Altogether, these results indicate that RTP801 has an important role modulating neuronal plasticity and motor learning. They will help to understand its role in neurodegenerative disorders where RTP801 levels are detrimentally upregulated.
Matèries (anglès)
Citació
Citació
PÉREZ SISQUÉS, Leticia, MARTÍN FLORES, Núria, MASANA NADAL, Mercè, SOLANA BALAGUER, Júlia, LLOBET, Arnau, ROMANÍ AUMEDES, Joan, CANAL DE LA IGLESIA, Mercè, CAMPOY CAMPOS, Genís, GARCÍA-GARCÍA, Esther, SÁNCHEZ FERNÁNDEZ, Núria, FERNÁNDEZ, Sara (fernández garcía), GILBERT, James p., RODRÍGUEZ ALLUÉ, Manuel josé, MAN, Heng-ye, FEINSTEIN, Elena, WILLIAMSON, David l., SOTO DEL CERRO, David, GASULL CASANOVA, Xavier, ALBERCH I VIÉ, Jordi, MALAGELADA GRAU, Cristina. RTP801 regulates motor cortex synaptic transmission and learning. _Experimental Neurology_. 2021. Vol. 342, núm. 113755. [consulta: 14 de gener de 2026]. ISSN: 0014-4886. [Disponible a: https://hdl.handle.net/2445/177519]