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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/181477
Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets The Result of Drug Substance Incorporation
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The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, x-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., 'locking' of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.
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JUSZCZYK, Ewelina, et al. Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets The Result of Drug Substance Incorporation. Materials. 2021. Vol. 14, num. 6531. ISSN 1996-1944. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/181477