Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

679660.pdf (244.12 KB)

Document type

Article

Version

Published version

Publication date

2018-12

Publication license

cc-by (c) Cambridge University Press, 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/154883

Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1017/S003329171800017X

Abstract

BACKGROUND: Obsessive-compulsive disorder (OCD) is common in clozapine-treated patients although the actual prevalence, phenomenology and risk factors remain unclear. The aim of the present study was to address the three aforementioned questions. METHODS: The electronic records of a large cohort of clozapine-medicated schizophrenia patients routinely screened for OCD were used. The Obsessive Compulsive Inventory Revised version (OCI-R) was available from 118 cases and a 21 points cut-off threshold for OCD was defined. RESULTS: OCD prevalence was 47%, higher in patients on poly-pharmacy than on monotherapy (64% vs 31%; p = 0.001). Two OCI-R factors had significantly higher scores and distinct risk factors: checking behaviour (mean = 5.1; SD = 3.6) correlated with length of clozapine treatment (r = 0.21; p = 0.026), and obsessing factor (mean = 4.8; SD = 3.6) correlated with psychosis severity (r = 0.59; p = 0.001). These factors along with total OCI-R, did not correlate with either clozapine dose or plasma levels, after correcting for psychosis severity. CONCLUSIONS: Screening for OCD in clozapine patients, and probably in those treated with structurally similar drugs with potent antiserotoninergic properties, should be widely adopted by clinicians. Further research is needed to understand the pathophysiology underlying repetitive behavior onset in clozapine-treated patients.

Subject

Esquizofrènia, Psiquiatria, Psicologia clínica

Subject (English)

Schizophrenia, Psychiatry, Clinical psychology

Citation

Collections

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

FERNÁNDEZ EGEA, Emilio, et al. Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia. Psychological Medicine. 2018. Vol. 48, num. 16, pags. 2668-2675. ISSN 0033-2917. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/154883

Export metadata

JSON - METS

Share record