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2022_SciRep_Circulating_MadridF.pdf (1.51 MB)

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2022-03-14

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cc by (c) Oliveras, Teresa et al, 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/186885

Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation

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https://doi.org/10.1038/s41598-022-08453-0

Abstract

Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. PUFA status in serum phospholipids is a valid surrogate biomarker of PUFA status in cardiomyocytes within a wide range of dietary PUFA. In this nested case-control study (n = 58 cases of STEMI-driven PVF, n = 116 control non-PVF STEMI patients matched for age, sex, smoking status, dyslipidemia, diabetes mellitus and hypertension) we determined fatty acids in serum phospholipids by gas-chromatography, and assessed differences between cases and controls, applying the Benjamini-Hochberg procedure on nominal P-values to control the false discovery rate (FDR). Significant differences between cases and controls were restricted to linoleic acid (LA), with PVF patients showing a lower level (nominal P = 0.002; FDR-corrected P = 0.027). In a conditional logistic regression model, each one standard deviation increase in the proportion of LA was related to a 42% lower prevalence of PVF (odds ratio = 0.58; 95% confidence interval, 0.37, 0.90; P = 0.02). The association lasted after the inclusion of confounders. Thus, regular consumption of LA-rich foods (nuts, oils from seeds) may protect against ischemia-driven malignant arrhythmias.

Subject

Infart de miocardi, Fibril·lació ventricular

Subject (English)

Myocardial infarction, Ventricular fibrillation

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citation

OLIVERAS, Teresa, et al. Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation. Scientific Reports. 2022. Vol. 12. ISSN 2045-2322. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/186885

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