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2016-04-14

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cc-by (c) Abulí, Anna et al., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/104289

Genetic Variants Associated with Colorectal Adenoma Susceptibility

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https://doi.org/10.1371/journal.pone.0153084

Abstract

Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.

Subject

Càncer colorectal, Genètica humana, Estudi de casos, Mutació (Biologia), Colonoscòpia

Subject (English)

Colorectal cancer, Human genetics, Case studies, Mutation (Biology), Colonoscopy

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

ABULÍ, Anna, et al. Genetic Variants Associated with Colorectal Adenoma Susceptibility. PLoS One. 2016. Vol. 11, num. 4, pags. e0153084. ISSN 1932-6203. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/104289

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