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Data de publicació

2016-04-14

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cc-by (c) Abulí, Anna et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/104289

Genetic Variants Associated with Colorectal Adenoma Susceptibility

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Recurs relacionat

https://doi.org/10.1371/journal.pone.0153084

Resum

Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.

Matèries

Càncer colorectal, Genètica humana, Estudi de casos, Mutació (Biologia), Colonoscòpia

Matèries (anglès)

Colorectal cancer, Human genetics, Case studies, Mutation (Biology), Colonoscopy

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

ABULÍ, Anna, et al. Genetic Variants Associated with Colorectal Adenoma Susceptibility. PLoS One. 2016. Vol. 11, num. 4, pags. e0153084. ISSN 1932-6203. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/104289

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