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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/104289
Genetic Variants Associated with Colorectal Adenoma Susceptibility
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Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.
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ABULÍ, Anna, CASTELLS GARANGOU, Antoni, BUJANDA, Luis, LOZANO SALVATELLA, Juan josé, BESSA I CASERRAS, Xavier, HERNÁNDEZ-MUNAIN, Cristina, ÁLVAREZ URTURI, Cristina, PELLISÉ URQUIZA, Maria, ESTEBAN-JURADO, Clara, HIJONA, Elizabeth, BURÓN, Andrea, MACIÀ, Francesc, GRAU CANO, J. (jaume), GUAYTA, Rafael (guayta escolies), CASTELLVÍ BEL, Sergi, ANDREU, Montserrat, TRILLA GARCÍA, Antoni, PROCOLON Research Group. Genetic Variants Associated with Colorectal Adenoma Susceptibility. _PLoS One_. 2016. Vol. 11, núm. 4, pàgs. e0153084. [consulta: 20 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/104289]