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2017-02-07

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cc-by-nc-nd (c) Cano Català, Marta et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/128805

Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study

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https://doi.org/10.1038/tp.2016.267

Resum

Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement. We assessed 12 patients with treatment-resistant depression (TRD) at four time points (pretreatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and 10 healthy participants at two time points, 5 weeks apart. Patients with TRD showed bilateral medial temporal lobe (MTL) and perigenual anterior cingulate cortex volume increases. Left MTL volume increase was associated with (i) a hippocampal N-acetylaspartate concentration decrease, (ii) a hippocampal Glutamate+ Glutamine concentration increase and (iii) significant clinical improvement. The observed findings are, in part, compatible with both neuroplastic and neuroinflammatory changes induced by ECT. We postulate that such phenomena may be interrelated, therefore reconciling the neuroplasticity and neuroinflammatory hypotheses of ECT action.

Matèries

Diagnòstic per la imatge, Cervell, Depressió psíquica, Resistència als medicaments, Electroxoc

Matèries (anglès)

Diagnostic imaging, Brain, Mental depression, Drug resistance, Electric shock

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

CANO CATALÀ, Marta, MARTÍNEZ ZALACAÍN, Ignacio, BERNABEU-SANZ, Ana ávila, CONTRERAS RODRÍGUEZ, Oren, HERNÁNDEZ RIBAS, Rosa, VIA VIRGILI, Esther, DE ARRIBA ARNAU, Aida, GALVEZ, Veronica, URRETAVIZCAYA SARACHAGA, Mikel, PUJOL NUEZ, Jesús, MENCHÓN MAGRIÑÁ, José manuel, CARDONER, N. (narcís), SORIANO MAS, Carles. Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study. _Translational Psychiatry_. 2017. Vol. 7, núm. 2, pàgs. e1023. [consulta: 24 de gener de 2026]. ISSN: 2158-3188. [Disponible a: https://hdl.handle.net/2445/128805]

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