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2021-01-04

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cc-by (c) Prat, Aleix et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175264

Clinical, pathological and PAM50 gene expression features of HER2-low breast cancer

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https://doi.org/10.1038/s41523-020-00208-2

Resum

Novel antibody-drug conjugates against HER2 are showing high activity in HER2-negative breast cancer (BC) with low HER2 expression (i.e., 1+ or 2+ and lack of ERBB2 amplification). However, the clinical and molecular features of HER2-low BC are yet to be elucidated. Here, we collected retrospective clinicopathological and PAM50 data from 3,689 patients with HER2-negative disease and made the following observations. First, the proportion of HER2-low was higher in HR-positive disease (65.4%) than triple-negative BC (TNBC, 36.6%). Second, within HR-positive disease, ERBB2 and luminal-related genes were more expressed in HER2-low than HER2 0. In contrast, no gene was found differentially expressed in TNBC according to HER2 expression. Third, within HER2-low, ERBB2 levels were higher in HR-positive disease than TNBC. Fourth, HER2-low was not associated with overall survival in HR-positive disease and TNBC. Finally, the reproducibility of HER2-low among pathologists was suboptimal. This study emphasizes the large biological heterogeneity of HER2-low BC, and the need to implement reproducible and sensitive assays to measure low HER2 expression.

Matèries

Càncer de mama, Expressió gènica

Matèries (anglès)

Breast cancer, Gene expression

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PRAT APARICIO, Aleix, SCHETTINI, Francesco, CHIC RUCHÉ, Núria, BRASÓ MARISTANY, Fara, PARÉ, Laia, PASCUAL, Tomás, CONTE, Benedetta, MARTÍNEZ SÁEZ, Olga, ADAMO, Barbara, VIDAL LOSADA, Maria jesús, FERNÁNDEZ MARTÍNEZ, Aranzazu, GONZÁLEZ FARRÉ, Blanca, SANFELIU, Esther, CEJALVO ANDÚJAR, Juan miguel, PERRONE, Giuseppe, SABARESE, Giovanna, ZALFA, Francesca, VILLAGRASA, Patricia, GAVILÁ, Joaquín, BARRIOS, Carlos  h., LLUCH, Ana, MARTÍN, Miguel, PLACIDO, Sabino de, BARNADAS, Esther, LOCCI, Mariavittoria, PEG, Vicente, FASAN, Roberta. Clinical, pathological and PAM50 gene expression features of HER2-low breast cancer. _Npj Breast Cancer_. 2021. Vol. 7. [consulta: 21 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/175264]

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