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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127216
Allosterism and signal transfer in DNA
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We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects.
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BALACEANU, Alexandra, PÉREZ, Alberto, DANS, Pablo d., OROZCO LÓPEZ, Modesto. Allosterism and signal transfer in DNA. _Nucleic Acids Research_. 2018. Vol. 46, núm. 15, pàgs. 7554-7565. [consulta: 27 de gener de 2026]. ISSN: 0305-1048. [Disponible a: https://hdl.handle.net/2445/127216]