Allosterism and signal transfer in DNA

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dc.contributor.authorBalaceanu, Alexandra
dc.contributor.authorPérez, Alberto
dc.contributor.authorDans, Pablo D.
dc.contributor.authorOrozco López, Modesto
dc.date.accessioned2019-01-11T18:03:12Z
dc.date.available2019-01-11T18:03:12Z
dc.date.issued2018-06-14
dc.date.updated2019-01-11T18:03:12Z
dc.description.abstractWe analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects.
dc.format.extent12 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec682925
dc.identifier.issn0305-1048
dc.identifier.pmid29905860
dc.identifier.urihttps://hdl.handle.net/2445/127216
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1093/nar/gky549
dc.relation.ispartofNucleic Acids Research, 2018, vol. 46, num. 15, p. 7554-7565
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/676556/EU//MuG
dc.relation.urihttps://doi.org/10.1093/nar/gky549
dc.rightscc-by-nc (c) Balaceanu, Alexandra et al., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationADN
dc.subject.classificationDinàmica molecular
dc.subject.classificationProteïnes
dc.subject.classificationLligands
dc.subject.otherDNA
dc.subject.otherMolecular dynamics
dc.subject.otherProteins
dc.subject.otherLigands
dc.titleAllosterism and signal transfer in DNA
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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