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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/47001
Current directions in DNA gel particles
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Abstract
A general understanding of interactions between DNA and
oppositely charged compounds forms the basis for developing novel
DNA-based materials, including gel particles. The association strength,
which is altered by varying the chemical structure of the cationic
cosolute, determines the spatial homogeneity of the gelation process,
creating DNA reservoir devices and DNA matrix devices that can be
designed to release either single- (ssDNA) or double-stranded
(dsDNA) DNA. This paper reviews the preparation of DNA gel
particles using surfactants, proteins and polysaccharides. Particle
morphology, swelling/dissolution behaviour, degree of DNA
entrapment and DNA release responses as a function of the nature of
the cationic agent used are discussed. Current directions in the
haemocompatible and cytotoxic characterization of these DNA gel
particles have been also included.
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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988
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MORÁN BADENAS, María del Carmen, et al. Current directions in DNA gel particles. Recent Advances in Pharmaceutical Sciences III. 2013. Vol. Transworld Research Network : Editors: Diego Muñoz Torrero, num. Mariño, pags. 145-162. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/47001