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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/164462
Highly enantioselective iridium-catalyzed hydrogenation of 2-aryl allyl phthalimides
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The iridium-catalyzed asymmetric hydrogenation of 2-aryl allyl phthalimides to afford enantioenriched β-aryl-β-methyl amines is presented. Recently developed Ir-MaxPHOX catalysts are used for this enantioselective transformation. The mild reaction conditions and the feasible removal of the phthalimido group makes this catalytic method easily scalable and of great interest to afford chiral amines. The importance of this new methodology is exemplified by the formal synthesis of (R)-Lorcaserin, OTS514 and enantiomerically enriched 3-methyl indolines.
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CABRÉ MONTESINOS, Albert, et al. Highly enantioselective iridium-catalyzed hydrogenation of 2-aryl allyl phthalimides. Organic Letters. 2019. Vol. 21, num. 23, pags. 9709-9713. ISSN 1523-7060. [consulted: 17 of October of 2026]. Available at: https://hdl.handle.net/2445/164462