Miniatura

Fitxers

674353.pdf (285.6 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2017-09-30

Llicència de publicació

cc-by-nc (c) Millares, Laura et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/125867

Specific IgA against Pseudomonas aeruginosa in severe COPD

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.2147/COPD.S141701

Resum

Background: The bronchial mucosa is protected by a specialized immune system focused on the prevention of colonization and infection by potentially pathogenic microorganisms (PPMs). Immunoglobulin A (IgA) is the principal antibody involved in this mechanism. A defective immune barrier may facilitate the recurrent presence of PPMs in COPD. Purpose: The aim of this study was to determine IgA-mediated bronchial specific immune responses against Pseudomonas aeruginosa in stable patients with severe disease. Methods: COPD patients with good-quality sputum samples obtained during stability were included and classified according to the presence or absence of chronic bronchial colonization by P. aeruginosa. Levels of specific IgA for P. aeruginosa in sputum were determined by ELISA and expressed as ratios, using the pooled level of 10 healthy subjects as reference (optical density450 patient/control). Results: Thirty-six stable COPD patients were included, 15 of whom had chronic colonization by P. aeruginosa. Levels of specific IgA against P. aeruginosa in stable non-colonized patients were lower than those in healthy subjects (IgA ratio: median =0.15 [interquartile range {IQR} 0.05-0.36]). Colonized patients had higher levels, (1.56 [IQR 0.59-2.79]) (p,0.001, Mann- Whitney U test), with figures equivalent but not exceeding the reference value. Conclusion: IgA-based immune response against P. aeruginosa was low in severe COPD patients. Levels of specific IgA against this microorganism were higher in colonized patients, but did not attain clear-cut levels above the reference. An impaired local response against P. aeruginosa may favor chronic colonization and recurrent infections in severe COPD.

Matèries

Immunoglobulina A, Enzimoimmunoassaig sobre fase sòlida, Esput

Matèries (anglès)

Immunoglobulin A, Enzyme-linked immunosorbent assay, Sputum

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MILLARES, Laura, MARTÍ MARTÍ, Sara, ARDANUY TISAIRE, María carmen, LIÑARES LOUZAO, Josefina, SANTOS PÉREZ, Salud, DORCA I SARGATAL, Jordi, GARCÍA NÚÑEZ, Marian, QUERO, Sara, MONSÓ, Eduard. Specific IgA against Pseudomonas aeruginosa in severe COPD. _International Journal of Chronic Obstructive Pulmonary Disease_. 2017. Vol. 12, núm. 2807-2811. [consulta: 28 de gener de 2026]. ISSN: 1176-9106. [Disponible a: https://hdl.handle.net/2445/125867]

Exportar metadades

JSON - METS

Compartir registre