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Structural Heart Alterations in Brugada Syndrome Is it Really a_ClinicalMedicine.pdf (527.18 KB)

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2022-07-28

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cc by (c) Oliva, Antonio et al, 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/199555

Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review

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https://doi.org/10.3390/jcm11154406

Abstract

Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes.

Subject

Mort sobtada, Malalties del cor

Subject (English)

Sudden death, Heart diseases

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

OLIVA, Antonio, et al. Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review. Journal Of Clinical Medicine. 2022. Vol. 11, num. 15. ISSN 2077-0383. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/199555

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