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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199555
Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review
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Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes.
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OLIVA, Antonio, GRASSI, Simone, PINCHI, Vilma, CAZZATO, Francesca, COLL, Mònica, ALCALDE, Mireia, VALLVERDÚ PRATS, Marta, PÉREZ SERRA, Alexandra, MARTÍNEZ BARRIOS, Estefanía, CÉSAR DIAZ, Sergio, IGLESIAS, Anna, CRUZALEGUI, José, HERNÁNDEZ, Clara, FIOL, Victoria, ARBELO, Elena, DÍEZ ESCUTÉ, Nuria, ARENA, Vincenzo, BRUGADA TERRADELLAS, Josep, SARQUELLA BRUGADA, Georgia, BRUGADA, Ramon, CAMPUZANO LARREA, Oscar. Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review. _Journal Of Clinical Medicine_. 2022. Vol. 11, núm. 15. [consulta: 1 de febrer de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/199555]