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glunt2018_3011.pdf (807.16 KB)

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2018-04

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cc by (c) Glunt et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/122195

Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets

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http://dx.doi.org/10.1111/eva.12574

Resum

In spite of widespread insecticide resistance in vector mosquitoes throughout Africa, there is limited evidence that long-lasting insecticidal bed nets (LLINs) are failing to protect against malaria. Here, we showed that LLIN contact in the course of host-seeking resulted in higher mortality of resistant Anopheles spp. mosquitoes than predicted from standard laboratory exposures with the same net. We also found that sublethal contact with an LLIN caused a reduction in blood feeding and subsequent host-seeking success in multiple lines of resistant mosquitoes from the laboratory and the field. Using a transmission model, we showed that when these LLIN-related lethal and sublethal effects were accrued over mosquito lifetimes, they greatly reduced the impact of resistance on malaria transmission potential under conditions of high net coverage. If coverage falls, the epidemiological impact is far more pronounced. Similarly, if the intensity of resistance intensifies, the loss of malaria control increases nonlinearly. Our findings help explain why insecticide resistance has not yet led to wide-scale failure of LLINs, but reinforce the call for alternative control tools and informed resistance management strategies.

Matèries

Anopheles, Malària

Matèries (anglès)

Anopheles, Malaria

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Articles publicats en revistes (ISGlobal)

Citació

GLUNT, Katey d., COETZEE, Maureen, HUIJBEN, Silvie, KOFFI, A. alphonsine, LYNCH, Penelope a., N'GUESSAN, Raphael, OUMBOUKE, Welbeck a., STERNBERG, Eleanore d., THOMAS, Matthew b.. Empirical and theoretical investigation into the potential
                impacts of insecticide resistance on the effectiveness of
                insecticide-treated bed nets. _Evolutionary Applications_. 2018. Vol. 11, núm. 4, pàgs. 431-441. [consulta: 24 de gener de 2026]. ISSN: 1752-4571. [Disponible a: https://hdl.handle.net/2445/122195]

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