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2022-02-01

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cc-by-nc-nd (c) Elsevier B.V., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225576

Evaluating maintenance electroconvulsive therapy in Bipolar Disorders: 3-year mirror-image study

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https://doi.org/10.1016/j.jad.2021.10.052

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Backgorund: Maintenance electroconvulsive therapy (mECT) is underused in the treatment of bipolar disorder (BD). We aimed to study the real-life effectiveness of mECT in BD. Methods: Naturalistic 3-year mirror-image study in individuals diagnosed with BD who underwent mECT at a tertiary hospital. Intra-subject comparisons of psychiatric hospitalization were performed using McNemar test. Days and number of psychiatric hospitalizations before and during mECT were compared through wilcoxon signed-rank test. Mean annual days and mean annual number of psychiatric hospitalizations per patient were compared by means of the rate ratio (RR) estimation through a generalized estimating equation (GEE) model. Results: A total of 43 patients were included and 37 required psychiatric hospitalization during the study. The use of mECT showed an effectiveness of 62.2% for preventing psychiatric hospitalizations (p<0.01). We found significant reduction in days and number of psychiatric hospitalizations during mECT compared to before mECT (p<0.01). Comparison of the 3-year period before/during mECT showed a reduction in mean annual days (RR=0.14; 95%CI: 0.07-0.29) and mean annual number (RR=0.24; 95%CI: 0.13-0.43) of psychiatric hospitalizations, without substantial changes for adjusted models for gender and age of onset of the illness. Limitations: The main limitations of this study consisted of the mirror-image retrospective naturalistic study design, the relatively small sample size, and possibly patient selection bias. Conclusions: mECT reduced the number of psychiatric hospitalizations and hospitalization days in BD. The use of mECT outlines a mood stabilizing effect in BD. This naturalistic study supports the effectiveness of mECT in BD across several mood states.

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Trastorn bipolar, Ingressos i altes en els hospitals, Avaluació

Matèries (anglès)

Manic-depressive illness, Hospital admission and discharge, Evaluation

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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MADERO GÓMEZ, Santiago, ANMELLA, Gerard, SAGUÉ VILAVELLA, Maria, PONS-CABRERA, Maria teresa, GIMÉNEZ PALOMO, Anna, MURRU, Andrea, GÓMEZ-RAMIRO, Marta, GIL BADENES, Joaquín, RÍOS, José, BIOQUE ALCÁZAR, Miquel, VIETA I PASCUAL, Eduard, BENABARRE, Antonio. Evaluating maintenance electroconvulsive therapy in Bipolar Disorders: 3-year mirror-image study. _Journal of Affective Disorders_. 2022. Vol. 298, núm. Pt A, pàgs. 58-64. [consulta: 21 de gener de 2026]. ISSN: 0165-0327. [Disponible a: https://hdl.handle.net/2445/225576]

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