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2017-01-03

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cc-by-nc-sa (c) Delgado-Morales, Raul; Esteller, Manel, 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/114032

Opening up the DNA methylome of dementia

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https://doi.org/10.1038/mp.2016.242

Abstract

Dementia is a complex clinical condition characterized by several cognitive impairments that interfere with patient independence in executing everyday tasks. Various neurodegenerative disorders have dementia in common among their clinical manifestations. In addition, these diseases, such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies and frontotemporal dementia, share molecular alterations at the neuropathological level. In recent years, the field of neuroepigenetics has expanded massively and it is now clear that epigenetic processes, such as DNA methylation, are mechanisms involved in both normal and pathological brain function. Despite the persistent methodological and conceptual caveats, it has been reported that several genes fundamental to the development of neurodegenerative disorders are deregulated by aberrant methylation patterns of their promoters, and even common epigenetic signatures for some dementia-associated pathologies have been identified. Therefore, understanding the epigenetic mechanisms that are altered in dementia, especially those associated with the initial phases, will allow us not only to understand the etiopathology of dementia and its progression but also to design effective therapies to reduce this global public health problem. This review provides an in-depth summary of our current knowledge about DNA methylation in dementia, focusing exclusively on the analyses performed in human brain.

Subject

Metilació, ADN, Demència, Malalties neurodegeneratives, Epigènesi

Subject (English)

Methylation, DNA, Dementia, Neurodegenerative Diseases, Epigenesis

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Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

DELGADO-MORALES, Raul and ESTELLER, Manel. Opening up the DNA methylome of dementia. Molecular Psychiatry. 2017. Vol. 22, num. 4, pags. 485-496. ISSN 1359-4184. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/114032

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