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2024-12

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cc by (c) Antón López, Jordi et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219511

Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study

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https://doi.org/10.1007/s00296-024-05658-6

Resum

To describe the characteristics of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), compare their presentation and evolution, and analyse possible complication predictors. Multicenter study. Data were retrieved from a hospital-based study of patients with a diagnosis or suspected diagnosis of sJIA or AOSD according to the responsible physician and followed-up for at least one year. Descriptive variables (classification criteria, clinical manifestations, complications, family, and personal history) were collected at disease onset and during follow-up. We present the clinical characteristics of 326 patients, 67% of whom had a diagnosis of sJIA and 33% of AOSD. Clinical manifestation frequencies were similar between the two groups, except for odynophagia, which was significantly more frequent in AOSD than in sJIA (78.4% vs. 25.5%; p < 0.0001). Among the complications, macrophage activation syndrome (MAS) was significantly more common in sJIA than in AOSD (24.4% vs. 9.5%; p = 0.002), to the extent that an sJIA diagnosis significantly increased the risk of MAS, together with serositis presence, and the need for biological therapy. Patients with sJIA and AOSD showed similar characteristics, supporting the idea that they are both part of Still's disease, but are expressed at different ages. Differences in manifestations and complications might be due to different management between diseases and immune response maturity.

Matèries

Artritis, Inflamació, Epidemiologia

Matèries (anglès)

Arthritis, Inflammation, Epidemiology

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ANTÓN LÓPEZ, Jordi, MOSQUERA ANGUITA, Juan manuel, CALZADA HERNÁNDEZ, Joan, IGLESIAS JIMÉNEZ, Estíbaliz, ZACARÍAS, Andrea, OLIVÉ, Alejandro, BITTERMANN, Violeta, RODRÍGUEZ LORENZO, Tania, REMESAL, Agustín, QUINTANA-ORTEGA, Cristian, NUÑO-NUÑO, Laura, ROBLES MARHUENDA, Ángel, DE INOCENCIO, Jaime, MARTÍN-LÓPEZ, María, CARREIRA, Patricia e., BRANDY-GARCÍA, Anahy m., HOLGADO, Susana, CAMACHO LOVILLO, Marisol, RUIZ-ROMÁN, Alberto, CLEMENTE, Daniel, NARVÁEZ GARCÍA, Francisco javier, CAMPOS, José, SÁNCHEZ MANUBENS, Judith, BERNABEU, Pilar, GRAÑA GIL, Jenaro, VARGAS LEBRÓN, Carmen, ORTIZ-SANTAMARIA, Vera, CASTAÑEDA, Sergio, GARCÍA DE YÉBENES, M.j., CARMONA, L.. Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study. _Rheumatology International_. 2024. Vol. 44, núm. 12, pàgs. 2911-2920. [consulta: 14 de gener de 2026]. ISSN: 0172-8172. [Disponible a: https://hdl.handle.net/2445/219511]

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