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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/187422
C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19
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Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551-0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001-1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865-0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188-1.819; p < 0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course.
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GINER GALVAÑ, Vicente, POMARES GÓMEZ, Francisco, QUESADA, José antonio, RUBIO RIVAS, Manuel, TEJADA MONTES, Javier, BALTASAR CORRAL, Jesús, TABOADA-MARTÍNEZ, María luisa, SÁNCHEZ MESA, Blanca, ARNALICH FERNÁNDEZ, Francisco, CORRAL BEAMONTE, Esther del, LÓPEZ SAMPALO, Almudena, PESQUEIRA FONTÁN, Paula maría, FERNÁNDEZ GARCÉS, Mar, GÓMEZ HUELGAS, Ricardo, RAMOS-RINCÓN, José manuel, SEMI-COVID-19 Network. C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19. _Biomedicines_. 2022. Vol. 10, núm. 6. [consulta: 23 de gener de 2026]. ISSN: 2227-9059. [Disponible a: https://hdl.handle.net/2445/187422]