Miniatura

Fitxers

685304.pdf (341.48 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2018-06-01

Llicència de publicació

cc by (c) Neumeyer et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172458

Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41416-018-0108-8

Resum

BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent. METHODS: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index. RESULTS: Genetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results. CONCLUSIONS: Our study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.

Matèries

Càncer colorectal, Menopausa

Matèries (anglès)

Colorectal cancer, Menopause

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

NEUMEYER, Sonja, BANBURY, Barbara l., ARNDT, Volker, BERNDT, Sonja i., BÉZIEAU, Stéphane, BIEN, Stephanie a., BUCHANAN, Daniel d., BUTTERBACH, Katja, CAAN, Bette j., CAMPBELL, Peter t., CASEY, Graham, CHAN, Andrew t., CHANOCK, Stephen j., DAI, James y., GALLINGER, Steven, GIOVANNUCCI, Edward l., GILES, Graham g., GRADY, William m., HAMPE, Jochen, HOFFMEISTER, Michael, HOPPER, John l., HSU, Li, JENKINS, Mark a., JOSHI, Amit, LARSSON, Susanna c., MARCHAND, Loïc le, LINDBLOM, Annika, MORENO AGUADO, Víctor, LEMIRE, Mathieu, LI, Li, LIN, Yi, OFFIT, Kenneth, NEWCOMB, Polly a., PHAROAH, Paul d. p., POTTER, John d., QI, Lihong, RENNERT, Gad, SCHAFMAYER, Clemens, SCHOEN, Robert e., SLATTERY, Martha l., SONG, Mingyang, ULRICH, Cornelia m., WIN, Aung k., WHITE, Emily, WOLK, Alicja, WOODS, Michael o., WU, Anna h., GRUBER, Stephen b., BRENNER, Hermann, PETERS, Ulrike, CHANG-CLAUDE, Jenny. Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. _British Journal of Cancer_. 2018. Vol. 118, núm. 12, pàgs. 1639-1647. [consulta: 31 de gener de 2026]. ISSN: 0007-0920. [Disponible a: https://hdl.handle.net/2445/172458]

Exportar metadades

JSON - METS

Compartir registre