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jcm-11-03769-v2.pdf (303.18 KB)

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2022-06-29

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cc by (c) Ramos Rincon, Jose Manuel et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/187949

Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry

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https://doi.org/10.3390/jcm11133769

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Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients >= 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were >= 80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29-0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22-0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19.

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COVID-19, SARS-CoV-2, Persones grans, Malalts hospitalitzats

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COVID-19, SARS-CoV-2, Older people, Hospital patients

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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RAMOS-RINCÓN, José manuel, LÓPEZ CARMONA, María dolores, COBOS PALACIOS, Lidia, LÓPEZ SAMPALO, Almudena, RUBIO RIVAS, Manuel, MARTÍN ESCALANTE, María dolores, COSSIO TEJIDO, Santiago de, TABOADA-MARTÍNEZ, María luisa, MUIÑO MIGUEZ, Antonio, ARESES MANRIQUE, Maria, MARTINEZ CILLEROS, Carmen, TUÑÓN DE ALMEIDA, Carlota, ABELLA VÁZQUEZ, Lucy, MARTÍNEZ GONZALEZ, Angel luís, DÍEZ GARCÍA, Luis felipe, RIPPER, Carlos jorge, ASENSI, Victor, MARTINEZ PASCUAL, Angeles, GUISADO VASCO, Pablo, LUMBRERAS BERMEJO, Carlos, GÓMEZ HUELGAS, Ricardo, The Semi-covid-19 Network. Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry. _Journal of Clinical Medicine_. 2022. Vol. 11, núm. 13, pàgs. 3769. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/187949]

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