Miniatura

Fitxers

Del HoyoL.pdf (491.39 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2015-11-18

Llicència de publicació

cc by (c) Hoyo et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126932

Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3389/fnbeh.2015.00301

Resum

Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains: nearly all adults show neuropathology of Alzheimer's disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of A beta peptides (A beta(40) and A beta(42)), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma A beta(42) concentrations, a higher DMR score and impaired communication skills (ABAS-II). The total word production and switching ability in SVFT were good indicators of plasma A beta(42) concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS.

Matèries

Síndrome de Down, Malaltia d'Alzheimer

Matèries (anglès)

Down syndrome

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

HOYO, Laura del, XICOTA, Laura, SÁNCHEZ BENAVIDES, Gonzalo, CUENCA ROYO, Aida, SOLA LLOPIS, Susana de, LANGOHR, Klaus, FAGUNDO, Ana beatriz, FARRÉ ALBALADEJO, Magí, DIERSSEN, Mara, TORRE FORNELL, Rafael de la. Semantic Verbal Fluency Pattern, Dementia Rating Scores and
Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down
Syndrome Young Adults. _Frontiers in Behavioral Neuroscience_. 2015. Vol. 9. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126932]

Exportar metadades

JSON - METS

Compartir registre