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2013-03-20

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cc-by-nc-sa (c) Rodríguez-Aznar, Eva et al., 2013
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/133609

Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons

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https://doi.org/10.1523/JNEUROSCI.4459-12.2013

Abstract

During the development of the nervous system the regulation of cell cycle, differentiation, and survival is tightly interlinked. Newly generated neurons must keep cell cycle components under strict control, as cell cycle re-entry leads to neuronal degeneration and death. However, despite their relevance, the mechanisms controlling this process remain largely unexplored. Here we show that Scratch2 is involved in the control of the cell cycle in neurons in the developing spinal cord of the zebrafish embryo. scratch2 knockdown induces postmitotic neurons to re-enter mitosis. Scratch2 prevents cell cycle re-entry by maintaining high levels of the cycle inhibitor p57 through the downregulation of miR-25. Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-entry.

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Micro RNAs, Mitosi, Neurones, Fisiologia, Factors de transcripció, Genètica, Metabolisme

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MicroRNAs, Mitosis, Neurons, Physiology, Transcription factors, Genetics, Metabolism

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Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

RODRÍGUEZ-AZNAR, Eva, BARRALLO GIMENO, Alejandro and NIETO, M. Angela. Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons. Journal of Neuroscience. 2013. Vol. 33, num. 12, pags. 5095-5105. ISSN 0270-6474. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/133609

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