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Longitudinal brain atrophy and CSF biomarkers in early-onset.pdf (3.51 MB)

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2021-01-01

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cc by-nc-nd (c) Contador Muñana, José Miguel et al, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/214362

Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer's disease

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https://doi.org/10.1016/j.nicl.2021.102804

Resum

There is evidence longitudinal atrophy in posterior brain areas in early-onset Alzheimer's disease (EOAD; aged < 65 years), but no studies have been conducted in an EOAD cohort with fluid biomarkers characterization. We used 3T-MRI and Freesurfer 6.0 to investigate cortical and subcortical gray matter loss at two years in 12 EOAD patients (A + T + N + ) compared to 19 controls (A-T-N-) from the Hospital Clínic Barcelona cohort. We explored group differences in atrophy patterns and we correlated atrophy and baseline CSF-biomarkers levels in EOAD. We replicated the correlation analyses in 14 EOAD (A + T + N + ) and 55 late-onset AD (LOAD; aged ? 75 years; A + T + N + ) participants from the Alzheimer's disease Neuroimaging Initiative. We found that EOAD longitudinal atrophy spread with a posterior-to-anterior gradient and beyond hippocampus/amygdala. In EOAD, higher initial CSF NfL levels correlated with higher ventricular volumes at baseline. On the other hand, higher initial CSF A?42 levels (within pathological range) predicted higher rates of cortical loss in EOAD. In EOAD and LOAD subjects, higher CSF t-tau values at baseline predicted higher rates of subcortical atrophy. CSF p-tau did not show any significant correlation. In conclusion, posterior cortices, hippocampus and amygdala capture EOAD atrophy from early stages. CSF A?42 might predict cortical thinning and t-tau/NfL subcortical atrophy.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Matèries

Malaltia d'Alzheimer, Encèfal

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Alzheimer's disease, Encephalon

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

CONTADOR MUÑANA, José miguel, PÉREZ MILLAN, Agnès, TORT MERINO, Adrià, BALASA, Mircea, FALGÀS MARTÍNEZ, Neus, OLIVES CLADERA, Jaume, CASTELLVI, Magda, LLADÓ PLARRUMANÍ, Albert, BOSCH CAPDEVILA, Beatriz, FERNÁNDEZ VILLULLAS, Guadalupe, RAMOS CAMPOY, Oscar, ANTONELL BOIXADER, Anna, BARGALLÓ ALABART, Núria​, SANCHEZ DEL VALLE DÍAZ, Raquel, SALA LLONCH, Roser, LLADÓ PLARRUMANÍ, Albert. Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer's disease. _Neuroimage-Clinical_. 2021. Vol. 32. [consulta: 23 de gener de 2026]. ISSN: 2213-1582. [Disponible a: https://hdl.handle.net/2445/214362]

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