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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/188899
Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal
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Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Result: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65). Conclusions: First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures.
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RUBÍN GARCÍA, María, MARTÍN, Vicente, VITELLI STORELLI, Facundo, MORENO AGUADO, Víctor, ARAGONÉS, Nuria, ARDANAZ, Eva, ALONSO MOLERO, Jéssica, JIMÉNEZ MOLEÓN, José juan, AMIANO, Pilar, FERNÁNDEZ TARDÓN, Guillermo, MOLINA BARCELÓ, Ana, ALGUACIL, Juan, CHIRLAQUE, María dolores, ÁLVAREZ ÁLVAREZ, Laura, PÉREZ GÓMEZ, Beatriz, DIERSSEN SOTOS, Trinidad, OLMEDO REQUENA, Rocío, GUEVARA, Marcela, FERNÁNDEZ VILLA, Tania, POLLÁN, Marina, BENAVENTE, Yolanda. Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal. _Gaceta Sanitaria_. 2021. Vol. 36, núm. 4, pàgs. 345-352. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/188899]