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Studies on the Regioselectivity of the Cyclization of Tryptophanol-Derived Oxazolopiperidone Lactams

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dc.contributor.authorAmat Tusón, Mercedes
dc.contributor.authorLlor Brunés, Núria
dc.contributor.authorSubrizi, Fabiana
dc.contributor.authorPérez Bosch, Maria
dc.contributor.authorMolins i Grau, Elies
dc.contributor.authorBosch Cartes, Joan
dc.date.accessioned2020-11-04T09:06:16Z
dc.date.available2020-11-04T09:06:16Z
dc.date.issued2013
dc.date.updated2020-11-04T09:06:16Z
dc.description.abstractCyclization of the lactam carbonyl on the indole ring in tryptophanol-derived oxazolopiperidone lactams 2 and 6, under the classical POCl3-promoted Bischler-Napieralski conditions and under neutral conditions via the corresponding thiolactam, has been studied. Whereas tricyclic lactam 2 only leads to products coming from an α-amidoalkylation process, bicyclic lactam 6 undergoes cyclization on the lactam carbonyl, leading to the expected indolo[2,3-a]quinolizidine derivatives.
dc.format.extent7 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec620578
dc.identifier.issn1434-193X
dc.identifier.urihttps://hdl.handle.net/2445/171749
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/ejoc.200
dc.relation.ispartofEuropean Journal of Organic Chemistry, 2013, p. 1246-1252
dc.relation.urihttps://doi.org/10.1002/ejoc.200
dc.rights(c) Wiley-VCH, 2013
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationLactames
dc.subject.classificationTriptòfan
dc.subject.classificationCompostos heterocíclics
dc.subject.classificationSíntesi orgànica
dc.subject.otherLactams
dc.subject.otherTryptophan
dc.subject.otherHeterocyclic compounds
dc.subject.otherOrganic synthesis
dc.titleStudies on the Regioselectivity of the Cyclization of Tryptophanol-Derived Oxazolopiperidone Lactams
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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