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2012-04-03

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cc-by (c) Pasarín, M. et al., 2012
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/43658

Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD

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http://dx.doi.org/10.1371/journal.pone.0032785

Resum

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Most morbidity associated with the metabolic syndrome is related to vascular complications, in which endothelial dysfunction is a major pathogenic factor. However, whether NAFLD is associated with endothelial dysfunction within the hepatic vasculature is unknown. The aims of this study were to explore, in a model of diet-induced overweight that expresses most features of the metabolic syndrome, whether early NAFLD is associated with liver endothelial dysfunction. Wistar Kyoto rats were fed a cafeteria diet (CafD; 65% of fat, mostly saturated) or a control diet (CD) for 1 month. CafD rats developed features of the metabolic syndrome (overweight, arterial hypertension, hypertryglyceridemia, hyperglucemia and insulin resistance) and liver steatosis without inflammation or fibrosis. CafD rats had a significantly higher in vivo hepatic vascular resistance than CD. In liver perfusion livers from CafD rats had an increased portal perfusion pressure and decreased endothelium-dependent vasodilation. This was associated with a decreased Akt-dependent eNOS phosphorylation and NOS activity. In summary, we demonstrate in a rat model of the metabolic syndrome that shows features of NAFLD, that liver endothelial dysfunction occurs before the development of fibrosis or inflammation.

Matèries

Malalties del fetge, Endoteli, Fibrosi pulmonar

Matèries (anglès)

Liver diseases, Endothelium, Pulmonary fibrosis

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Articles publicats en revistes (Medicina)

Citació

PASARÍN CASTELLANOS, Marcos, LA MURA, Vincenzo, GRACIA-SANCHO, Jorge, GARCÍA CALDERÓ, Héctor, RODRÍGUEZ VILARRUPLA, Aina, GARCÍA PAGÁN, Juan carlos, BOSCH I GENOVER, Jaume, GONZÁLEZ-ABRALDES IGLESIAS, Juan. Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD. _PLoS One_. 2012. Vol. 7, núm. 2, pàgs. e32785. [consulta: 23 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/43658]

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