Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds

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dc.contributor.authorSolé Arjó, Daniel
dc.contributor.authorMariani, Francesco
dc.contributor.authorBennasar Fèlix, M. Lluïsa
dc.contributor.authorFernández Cadenas, Israel
dc.date.accessioned2019-01-30T13:51:43Z
dc.date.available2019-01-30T13:51:43Z
dc.date.issued2016-04-15
dc.date.updated2019-01-30T13:51:43Z
dc.description.abstractA palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp3)−C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)−H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec659135
dc.identifier.issn1433-7851
dc.identifier.pmid27079473
dc.identifier.urihttps://hdl.handle.net/2445/127737
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/anie.201602020
dc.relation.ispartofAngewandte Chemie-International Edition, 2016, vol. 55, num. 22, p. 6467-6470
dc.relation.urihttps://doi.org/10.1002/anie.201602020
dc.rights(c) Wiley-VCH, 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationPal·ladi (Element químic)
dc.subject.classificationCatàlisi
dc.subject.classificationSíntesi orgànica
dc.subject.classificationComplexitat computacional
dc.subject.classificationQuímica organometàl·lica
dc.subject.otherPalladium
dc.subject.otherCatalysis
dc.subject.otherOrganic synthesis
dc.subject.otherComputational complexity
dc.subject.otherOrganometallic chemistry
dc.titlePalladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)