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2016-04-15

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127737

Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds

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Abstract

A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp3)−C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)−H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step.

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https://doi.org/10.1002/anie.201602020

Subject

Pal·ladi (Element químic), Catàlisi, Síntesi orgànica, Complexitat computacional, Química organometàl·lica

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Palladium, Catalysis, Organic synthesis, Computational complexity, Organometallic chemistry

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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SOLÉ ARJÓ, Daniel, et al. Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds. Angewandte Chemie-International Edition. 2016. Vol. 55, num. 22, pags. 6467-6470. ISSN 1433-7851. [consulted: 16 of October of 2026]. Available at: https://hdl.handle.net/2445/127737

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